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However, Koch never credited the Hesses for their discovery of bacteriological agar, perhaps because, at the time, he failed to recognize its importance. Even after he received the insight about agar from the Hesses, Koch stuck with gelatine for years. In 1883-84, during his first medical expedition to Egypt and India to investigate cholera, he tried and failed to grow the cholera bacterium on gelatine media in the hot climate of Cairo (despite using a half-open fridge for incubation), only succeeding in the colder winter of Calcutta.，这一点在旺商聊官方下载中也有详细论述
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Read the full story at The Verge.
The problem gets worse in pipelines. When you chain multiple transforms — say, parse, transform, then serialize — each TransformStream has its own internal readable and writable buffers. If implementers follow the spec strictly, data cascades through these buffers in a push-oriented fashion: the source pushes to transform A, which pushes to transform B, which pushes to transform C, each accumulating data in intermediate buffers before the final consumer has even started pulling. With three transforms, you can have six internal buffers filling up simultaneously.