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Humanity had few explosives other than gunpowder until 1847 when Ascanio Sobrero created nitroglycerin by combining nitric and sulfuric acid with a fat extract called glycerin. Sobrero found it too volatile for use as an explosive and turned to medical uses. After a self-experiment, he reported that ingesting nitroglycerin led to “a most violent, pulsating headache accompanied by great weakness of the limbs”. (He also killed his dog.) Eventually this led to the use of nitroglycerin for heart disease.
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