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The hormone that these drugs mimic – GLP-1 – is not only produced in the gut. It is also active in the brain, where the receptors it binds to cluster in regions governing reward, motivation and stress – the same circuitry that gets hijacked by addiction. At therapeutic doses, GLP-1 drugs cross the blood-brain barrier and dampen dopamine signaling in the brain’s core reward center, making addictive substances less rewarding.
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- What's the recovery path if it breaks in a way they don't immediately understand?
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距离铁路口岸不远处的公路口岸，待检的进出口车辆正有序通过验放。“改革后公路口岸进出境车辆通行时间压缩85.5%，为企业节省了大量通关成本。”说起公路口岸的变化，李兰代表语气里透着欣喜。