O'Farrell said his weight loss with the drug was "almost instant" and that, as well as losing more than five stone (34kg) so far, he has more energy and has been able to exercise for the first time in years.
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The next year, PacBio developed a new method to allow multiple sequencing passes on the same DNA molecule. Double stranded DNA templates were ligated to two single stranded adapters, creating what the company called a “SMRTbell template.” Sequencing began at a primer on one of the adaptors and could proceed multiple times per molecule due to circularization, in a process called rolling-circle amplification. This helped reduce PacBio’s error rates significantly.
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